π Lab
Research

Measuring structure, then predicting it.

Our work sits where advanced imaging, full-field measurement and machine learning meet. We image specimens while they deform, extract quantitative fields from those volumes, and train models that predict behaviour rather than merely describe it.

Themes

Four directions

Distinct methods, one shared pipeline from specimen to model.

Tissue mechanics from tomography

In‑situ X-ray tomography of bone and soft tissue under load, with digital volume correlation and learned models that infer internal deformation from greyscale alone.

Flagship model · D2IM

Hyperspectral imaging for healthcare

The spectral signature of tissue carries biochemical state alongside structure. We build diffusion-based architectures for classification and tumour detection.

Models · DiffSpectralNet, MedDiffHSI

AI-driven biomaterial design

Predicting and optimising the hierarchical self-assembly of nanoparticles into macroscale soft biomaterials, including formulation with diffusion-language models.

Bio-inspired engineering

Quantum representation of images

Quantum-native representations of tissue images, enabling efficient classification, segmentation, measurement and multimodal fusion in the quantum space.

Quantum-AI synergy

Models

Published architectures

Named models from the lab, with the papers behind them.

Figure panels from the lab's published work: multi-scale tomography with digital volume correlation, D2IM data-driven image mechanics, hyperspectral classification with MedDiffHSI, and bio-inspired materials
Selected figuresFrom the published work below
D2IMDeformation from greyscale

Predicts bone deformation directly from X-ray tomography greyscale, without an explicit correlation step. Under active extension with segmentation models and large language models.

Extreme Mechanics Letters10.1016/j.eml.2024.102202
Also underway

New directions

Interdisciplinary work in progress across the lab and its affiliates.

AI digital volume correlation of hard & soft tissue Vision transformers for tissue modelling Diffusion architectures for data-driven mechanics Collaborative diffusion for multi-modal image analysis Biomaterial formulation with diffusion-language models Bone biomimetic materials via AI sonification Measurement in the quantum space